Predicted protein complexes
From a protein-protein interaction dataset by Collins et al., we predicted protein complexes and overlapping complexes using the method ClusterONE as described in Nepusz T, Yu H, Paccanaro A., Detecting overlapping protein complexes in protein-protein interaction networks. Nat Methods (2012).
Nodes - Number of nodes in the cluster
Quality - The quality of the cluster, measured by the in-weight divided by the sum of the in-weight and the out-weight. A good cluster contains many heavyweight in-weights, and it is connected to the rest of the network only by a few lightweight edges.
P-value - The p-value of a one-sided Mann-Whitney U test performed on the in-weights and out-weights of the vertices. A low p-value means that it is more likely that the cluster is a valid finding and not the result of random fluctuations.
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